POOR ORAL HYGIENE CAN CAUSE METABOLIC SYNDROME

- kwietnia 22, 2022 POOR ORAL HYGIENE CAN CAUSE METABOLIC SYNDROME - April 10, 2022 POOR ORAL HYGIENE CAN CAUSE METABOLIC SYNDROME Poor oral hygiene may cause metabolic syndrome Periodontal or gingival diseases are considered a significant risk factor for the occurrence of metabolic syndrome. the development of heart disease and diabetes. In a new study, researchers from Tokyo Medical and Dental University (TMDU) found that infection with Porphyromonas gingivalis, the bacterium that causes periodontal disease, disrupts the metabolism of skeletal muscle, a precursor to metabolic syndrome, by altering the composition of the gut microbiome. It has long been known that periodontal bacteria cause inflammation in the oral cavity, but also increase inflammation mediators systematically. As a result, long-term infection with periodontal bacteria can lead to weight gain and an increase in insulin resistance, which is the hallmark of type 2 diabetes. The function of insulin is to help transport glucose from the blood into the tissues, and above all into the skeletal muscle, where a quarter of it is stored. whole glucose. Interestingly, insulin resistance plays a key role in the development of Metabolic Syndrome, a group of conditions that include obesity, altered lipid metabolism, high blood pressure, high blood glucose, and systemic inflammation. Although skeletal muscle plays a key role in lowering blood glucose levels, a direct relationship between periodontal bacterial infection and the metabolic function of skeletal muscle has not yet been established. - Metabolic syndrome has become a common health problem in developed countries. The aim of our study was to find out how periodontal bacterial infection can lead to metabolic changes in skeletal muscles and thus the development of metabolic syndrome, said Kazuki Watanabe, one of the authors of the study.To achieve this goal, scientists first tested antibodies against Porphyromonas gingivalis in the blood patients with metabolic syndrome and found a positive correlation between antibody titers and increased insulin resistance. These results showed that patients with metabolic syndrome were likely to be infected with Porphyromonas gingivalis, and thus developed an immune response with antibodies to the germ. To understand the mechanism behind clinical observation, scientists then turned to using an animal model. When mice fed a high-fat diet (a prerequisite for the development of metabolic syndrome) orally administered Porphyromonas gingivalis, these mice developed increased insulin resistance, fat infiltration, and lower skeletal muscle glucose uptake compared to mice that did not ingest these bacteria. But how was this bacterium capable of causing systemic inflammation and metabolic syndrome? To answer this question, researchers focused on the gut microbiome, the network of bacteria present in the gut with which the body symbiotically coexists. Interestingly, the researchers found that in mice given Porphyromonas gingivalis, the gut microbiome was significantly altered, which could reduce insulin sensitivity. 'These are surprising results and provide insight into the mechanism underlying the relationship between Porphyromonas gingivalis infection and the development of metabolic syndrome and skeletal muscle metabolic dysfunction,' said Prof. Sayaka Katagiri, co-author of the study. I recommend using the Oman root combined with a eucalyptus leaf, rinsing the mouth and drinking inside the body, because gum pain may occur, you should make a chestnut tincture with alcohol and lubricate the gums with it